NEWS ABOUT THE CURE

Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies

Dr. Dun’s latest research helps to outline key attributes between DIPG and DMGs and how we might best find complementary strategies to attack DMG to improve prognoses.  This, when combined with further genetic analysis, will lead to improved outcomes for children fighting these brain tumors. Abstract Diffuse midline glioma (DMG) is a deadly pediatric and adolescent central nervous system (CNS) tumor localized along the midline structures of the brain atop the spinal cord. With a median overall s

Dosing Optimization of CED Drug Delivery for DIPG

A recent publication in the Journal of Neurosurgery highlighted Dr. Souweidane's efforts to leverage software in order to better predict CED drug delivery in DIPG patients. This may improve researchers' ability to optimize dosing for drugs delivered by CED, such as chemotherapy. CED administration in DIPG patients is largely thanks to research funding by The Cure Starts Now. Abstract With increasing use of convection-enhanced delivery (CED) of drugs, the need for software that can predict infusi

Groundbreaking Brain Cancer Trial Funded by Local Charities Demonstrates 2/3 Survival of Mice and Heads to Human Trials

Every year around 200-400 children die from the incurable brain tumor, Diffuse Intrinsic Pontine Glioma (DIPG) in the US and Australia. The average age of diagnosis for DIPG is just seven years old. There are no effective treatments, and average survival is from 12-18 months. A paper published in the prestigious journal, Nature Communications, reveals a revolutionary drug combination that – in animal studies and in world first 3D models of the tumor – is “spectacularly effective in eradicating t

Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG

In 2019 Dr. Maria Tsoli and Dr. David Ziegler of Children's Cancer Institute proposed developing new epigenetic combination treatments against DIPG. This project was approved for funding by the DIPG/DMG Collaborative and The Cure Starts Now and here are the results: Abstract Diffuse intrinsic pontine glioma (DIPG) is an aggressive and incurable childhood brain tumor for which new treatments are needed. CBL0137 is an anti-cancer compound developed from quinacrine that targets facilitates chromati

Australian Researchers Find New Way to Target Deadly Childhood Cancer With CBL0137

The following work was supported by grants from The Cure Starts Now and the DIPG/DMG Collaborative. Research by Australian scientists could pave the way to a new treatment for a currently incurable brain cancer in children called Diffuse Intrinsic Pontine Glioma, or DIPG. Affecting about 150-300 children in US each year, DIPG is a devastating disease with a median survival range of 8-11 months, according to DIPG.org. The research, led by scientists at Children’s Cancer Institute and published th

The Do's and Don'ts of Helping a Friend Whose Child is Battling Cancer

A cancer diagnosis is life-altering but when the diagnosis is for your child, life is thrown off its axis and becomes complete chaos. For parents whose child is undergoing treatment, the road is exhausting and never-ending, leaving them with little time for anything other than taking care of their child. There are many things people can do and should not do when supporting friends who are dealing with a childhood cancer diagnosis. We have compiled a list of Do’s and Don’ts to help you navigate t

Breakthrough International Cancer Trial Halts Tumor Growth

The Cure Starts Now Foundation funds novel trial that halts tumor growth in 2/3 of study CINCINNATI | February 18, 2021 – The Cure Starts Now announced that the Polyamine Pathway Metabolism as a Novel Therapeutic Option for Diffuse Intrinsic Pontine Glioma (DIPG) grant, funded in partnership with the DIPG/DMG Collaborative, has resulted in the identification of a potentially revolutionary new drug treatment for brain cancer. In pre-clinical mouse model testing, researchers found the promising

Researchers Identify/Advance Potential Revolutionary New Drug Treatment for DIPG / DMG As Part of a Collaborative Foundational Partnership

Every year around 200-400 children die from the incurable brain tumor, Diffuse Intrinsic Pontine Glioma (DIPG) in the US and Australia. The average age of diagnosis for DIPG is just seven years. There are no effective treatments, and average survival is from 12-18 months. A paper published yesterday in the prestigious journal, Nature Communications, reveals a potential revolutionary drug combination that – in animal studies and in world first 3D models of the tumor – is “spectacularly effective

Childhood Cancer Talk Radio with Janet Demeter Featuring The Cure Starts Now’s Keith Desserich

Childhood Cancer Talk Radio promotes awareness of this very real and prevalent disease by providing a forum for conversation and advocacy in a growing community of affected families. Disclaimer: This transcription is not the production of TogiNet Radio, Beck Multimedia or Jack's Angels Foundation but was provided by The Cure Starts Now. The original podcast can be found here. Janet Demeter:Welcome to Childhood Cancer Talk Radio where kids come first for the cure. I'm Janet Demeter your host, an

Cincinnati Girl Raises Over $50,000 For Charity in Honor of Late Twin Brother

To Honor Her Twin Brother, Grant, Who Passed Away From Brain Cancer, 7-Year-Old Julia Wolf, Turned an $8 Request Into Funding of a Full Research Grant Ahead of Their 8th Birthday. CINCINNATI | February 9, 2021 -- The Cure Starts Now announced today that 7-year-old Julia Wolf’s “$8 by our 8th Birthday” Facebook fundraiser honoring her late twin brother, Grant, has raised over $50,000 for cancer research. The fundraiser surpassed her initial goal of $240 within the first hour on Thursday, February